Folic acid is an important nutrient for women who may become pregnant. Adequate folate intake during the periconceptional period, the time just before and just after a woman becomes pregnant, helps protect against a number of congenital malformations including neural tube defects. Supplementation with folic acid has been shown to reduce the risk of congenital heart defects, cleft palate, limb defects and urinary tract anomalies.Women who could become pregnant are advised to eat foods fortified with folic acid or take supplements in addition to eating folate-rich foods to reduce the risk of some serious birth defects. Taking 400 micrograms of synthetic folic acid daily from fortified foods and/or supplements has been suggested. The Recommended Dietary Allowance (RDA) for folate equivalents for pregnant women is 600-800 micrograms, twice the normal RDA of 400 micrograms for women who are not pregnant.
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BP2003 |
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Items |
Specification |
Results |
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Appearance |
Yellow or orange crystalline powder, almost odorless. |
Conform |
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Solubility |
Practically insoluble in water and in most organic solvents. It dissolves in dilute acids and in alkaline solutions. |
Conform |
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Identification |
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Specific optical rotation |
+18～+22° |
18.38 |
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Examine the chromatograms obtained in the assay |
The principal peak in the chromatogram obtained with the east solution is similar in retention time to the principal peak in the chromatogram obtained with reference solution |
Conform |
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Thin-layer chromatography |
The principal spot in the chromatogram obtained with the test solution is similar in position, fluorescence and size to the principal spot in the chromatogram obtained with the reference solution |
Conform |
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Related substances |
Conform to BP2003 |
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Water |
5.0～8.5% |
7.805 |
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Sulphated ash |
Maximum 0.2% |
96.05% |
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Assay |
96.0～102.0% |
96.05% |
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conclusion |
Conform to BP2003 |
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USP28 |
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Items |
Specification |
Results |
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Appearance |
Yellow or orange crystalline powder, almost odorless |
Conform |
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Identification |
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Ultraviolet absorption
A256/A365 |
Between 2.80 and 3.00 |
2.87 |
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Water |
Not more than 8.5% |
8.07% |
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Residue on ignition |
Not more than 0.3% |
0.09% |
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Chromatographic purity |
Not greater than 2.0% |
Conform |
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Organic volatile impurities |
Meet the requirements |
Conform |
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Assay |
97.0～102.0% |
97.16% |
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Conclusion |
Conform to USP28 |
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Contact：Ethan，Email：ethan@gardenchem.com |
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